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    25-03-2010
    Klik hier om een link te hebben waarmee u dit artikel later terug kunt lezen.Fact sheet Diabetes and obesity

    Obesity and diabetes: the link

    The prevalence of obesity is rising to epidemic proportions worldwide.  In some countries, an astonishing half of the population is overweight. Being overweight or obese seriously increases an individual’s risk of developing other health problems such as type 2 diabetes, coronary heart disease, and some forms of cancer.

    In both men and women, the more overweight an individual is, the greater the risk of developing type 2 diabetes. The means by which excessive body fat causes type 2 diabetes is not clearly defined, but it appears that excess fat increases insulin resistance, raising blood glucose levels and the likelihood of developing diabetes.  People with a greater amount of abdominal fat have a higher risk of developing the condition.

    Diabetes is the most preventable consequence of the obesity epidemic. Figures from the International Obesity Task Force (IOTF) suggest that up to 1.7 billion of the world’s population are already at a heightened risk of weight-related non-communicable diseases such as type 2 diabetes and cardiovascular disease. In fact, the risk in type 2 diabetes appears to be mainly related to the increasing prevalence of overweight and obese individuals worldwide. One in three Americans born today is predicted to develop diabetes as a consequence of obesity.

     

    Prevention

     

    Although obesity can affect anyone, the main risk factors are high-fat, high-energy dense diets and physical inactivity. Growing trends in many countries portray an ‘obesogenic’ society where the consumption of high-fat, high energy dense food is preferred to healthy fresh fruit and vegetables, and where the level of physical activity has dramatically been reduced or substituted by the constant usage of motor vehicles.

    The importance of eating a low-fat, low-energy dense diet and participating in physical activity should be greatly promoted in order to reduce the risks of becoming overweight or obese. If these habits are introduced in children, there is a greater chance that they will continue into adulthood.

    Public health programmes should stress the importance of a healthy environment, promoting improved diet and activity throughout communities. National programmes should be especially aimed at improving education and awareness of obesity and its consequences in schools and in youth recreational centres.

     

    Treatment options

     

    Weight management is the best strategy to prevent the development of type 2 diabetes. Research has shown that even a small amount of weight loss can decrease or slow down the risk of developing type 2 diabetes. Group therapy is advised to improve the psychological approach to weight loss, and to maintain an appropriate weight. Drugs to assist weight loss play a role in individuals for whom lifestyle changes alone may be insufficient to produce the required weight loss.

    Facts

    • The prevalence of obesity is rising to epidemic proportions at an alarming rate in both developed and developing countries worldwide.
    • Overweight and obesity affect over half the world’s population and diabetes rates are climbing to 20% of all adults in many Middle Eastern, Asian, and Latin American countries.
    • Two thirds of adult men and women in the US with type 2 diabetes have a BMI of 27 or greater.
    • It is estimated that at least half of all diabetes cases would be eliminated if weight gain in adults could be prevented.
    • Non-communicable diseases such as diabetes now account for more deaths each year worldwide than AIDS.
    • The twin epidemics of obesity and diabetes already represent the biggest public health challenge of the 21st century.
    • Lifestyle interventions, including diet and moderate physical activity, can reduce the risk of developing type 2 diabetes by as much as 40-60%.

    Links

    International Association for the Study of Obesity (IASO)
    International Obesity Task Force (IOTF) 

     

    References

     

    Diabetes Atlas, International Diabetes Federation, 2003.
    Diabetes and Obesity: Time to Act, International Diabetes Federation, 2004.

    Download the Executive Summary of Diabetes and Obesity: Time to Act (pdf file).

    Articles on diabetes and obesity published in Diabetes Voice:

    25-03-2010, 19:14 Geschreven door diabetesinsiders  

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    Tags:fact sheet diabetes and obesity
    Klik hier om een link te hebben waarmee u dit artikel later terug kunt lezen.Diabetes Logos

    The logos available are displayed below: 

     





    MENA logo







    25-03-2010, 19:10 Geschreven door diabetesinsiders  

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    Tags:diabetes logos
    Klik hier om een link te hebben waarmee u dit artikel later terug kunt lezen.Prevention

    Prevention

    Public and professional awareness of the risk factors for and the symptoms of diabetes are an important step towards its control and prevention.

    Diabetes prevention can be categorized into two groups:

    • Primary prevention
    • Secondary prevention

    Primary prevention identifies and protects individuals at risk from developing diabetes. It therefore has an impact by reducing both the need for diabetes care and the need to treat diabetes-related complications.

    While there is yet no conclusive evidence to suggest that type 1 diabetes can be prevented, primary prevention of type 2 diabetes is potentially possible.

    Lifestyle changes aimed at weight control and increased physical activity are important objectives in the prevention of type 2 diabetes. The benefits of reducing body weight and increasing physical activity are not confined to type 2 diabetes; they also play a role in reducing heart disease, high blood pressure, etc.

    Secondary prevention involves the early detection and prevention of complications, therefore reducing the need for treatment.

    Action taken early in the course of diabetes is more beneficial in terms of quality of life and is more cost-effective, especially if this action can prevent hospitalization.

    There is now conclusive evidence that good control of blood glucose levels can substantially reduce the risk of developing complications and slow their progression in all types of diabetes. The management of high blood pressure and raised blood lipids (fats) is equally important.

    Prevention in developing countries

    As the developing world is expected to bear the brunt of the escalating diabetes epidemic in the future, diabetes prevention is proving especially urgent and difficult in developing countries.

    In most developing countries, health policies and services need to put more emphasis on non-communicable diseases such as diabetes, but in many of these countries (as well as in developed ones) decision-makers lack awareness of diabetes and the political will to invest in prevention.

    The resources required for future research need to be found. Standards in diabetes monitoring and surveillance need to be set in countries where progress has been limited. 

    25-03-2010, 18:56 Geschreven door diabetesinsiders  

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    Categorie:overheidinformatie
    Tags:Prevention
    Klik hier om een link te hebben waarmee u dit artikel later terug kunt lezen.What are the warning signs of diabetes?

    What are the warning signs of diabetes?

    Individuals can experience different warning signs, and sometimes there may be no obvious warning, but some of the signs are commonly experienced:

    Type 1 diabetes

    The onset of type 1 diabetes is usually sudden and dramatic and can include symptoms such as:

    • Abnormal thirst and a dry mouth
    • Frequent urination
    • Extreme tiredness/lack of energy 
    • Sudden weight loss
    • Slow-healing wounds
    • Recurrent infections
    • Blurred vision

    Type 2 diabetes

    The same symptoms that are listed above can also affect people with type 2 diabetes, but they are usually less obvious. The onset of type 2 diabetes is gradual and therefore hard to detect. Indeed, some people with type 2 diabetes show no obvious symptoms early on. These people are often diagnosed several years later, when various complications are already present.

    People who think they might have diabetes should consult a healthcare professional.

    25-03-2010, 18:55 Geschreven door diabetesinsiders  

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    Tags:What are the warning signs of diabetes?
    Klik hier om een link te hebben waarmee u dit artikel later terug kunt lezen.Why you should care

    Why you should care

    The statistics are frightening . . .

    • In 1985, there were an estimated 30 million people with diabetes worldwide.
    • Today there are more than 245 million people with diabetes, over a seven-fold increase in just over 20 years.
    • If nothing is done to slow down the epidemic, within 20 years the number of people with diabetes will reach 380 million.

    The burden on healthcare systems is overwhelming . .

    The statistics are frightening . . .

    • In 1985, there were an estimated 30 million people with diabetes worldwide.
    • Today there are more than 245 million people with diabetes, over a seven-fold increase in just over 20 years.
    • If nothing is done to slow down the epidemic, within 20 years the number of people with diabetes will reach 380 million.

    The burden on healthcare systems is overwhelming . . .

    • It is estimated that the costs of diabetes complications account for between 5% and 10% of total healthcare spending in the world.

    The cost in human suffering and lives is heartbreaking . . .

    • Diabetes is the main cause of partial vision loss and blindness in adults in developed countries.
    • Diabetes accounts for the majority of limb amputations that are not the result of an accident.
    • People with diabetes are much more likely to have a heart attack or a stroke.
    • People with diabetes are at a greater risk of developing kidney disease.

    25-03-2010, 18:53 Geschreven door diabetesinsiders  

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    Tags:Why you should care
    Klik hier om een link te hebben waarmee u dit artikel later terug kunt lezen.Types of diabetes

    Types of diabetes

    There are two main types of diabetes:

    Type 1 diabetes is sometimes called insulin-dependent, immune-mediated or juvenile-onset diabetes. It is caused by an auto-immune reaction where the body’s defence system attacks the insulin-producing cells. The reason why this occurs is not fully understood. People with type 1 diabetes produce very little or no insulin. The disease can affect people of any age, but usually occurs in children or young adults. People with this form of diabetes need injections of insulin every day in order to control the levels of glucose in their blood. If people with type 1 diabetes do not have access to insulin, they die.

    Type 2 diabetes is sometimes called non-insulin dependent diabetes or adult-onset diabetes. People with type 2 diabetes do not usually require injections of insulin. Usually they can control the glucose in their blood by watching their diet, taking regular exercise, oral medication, and possibly insulin.

    Type 2 diabetes is most common in people older than 45 who are overweight. However, as a consequence of increased obesity among the young, it is becoming more common in children and young adults. Type 2 diabetes is the most common type of diabetes and accounts for 90-95% of all diabetes.

    If people with type 2 diabetes are not diagnosed and treated, they can develop serious complications, which can result in an early death. Worldwide, many millions of people have type 2 diabetes without even knowing it. Others do not have access to adequate medical care. The onset of type 2 diabetes is also linked to genetic factors but obesity, physical inactivity and unhealthy diet increase the risks.

    Some women develop a third, usually temporary, type of diabetes called ‘gestational diabetes’ when they are pregnant. Gestational diabetes develops in 2-5% of all pregnancies but usually disappears when the pregnancy is over. Women who have had gestational diabetes have an increased risk of developing type 2 diabetes later on.

    Other rarer types of diabetes also exist.

    25-03-2010, 18:53 Geschreven door diabetesinsiders  

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    Tags:Types of diabetes
    Klik hier om een link te hebben waarmee u dit artikel later terug kunt lezen.Who gets diabetes?

    Who gets diabetes?

    Anyone, anywhere, at any age can develop diabetes

    Many adults have had diabetes for several years before their symptoms are recognised. By the time they are diagnosed, a great many have already started to develop the complications of diabetes - visual impairment, kidney failure, heart disease, stroke and nerve damage. In many parts of the world, people with diabetes are not diagnosed at all.

    Spotting diabetes early means that it can be treated and the risk of the serious complications can be greatly reduced.

    A number of factors contribute to the likelihood of someone developing diabetes.

    Risk factors for type 1 diabetes:

    These are not very well defined, but it would appear that genetic and environmental factors could trigger the development of this type of diabetes. If there is someone in your family who has diabetes, then your chances of developing the disease are increased.

    Risk factors for type 2 diabetes:

    • Age

    90-95% of people with diabetes have type 2 diabetes. This type usually occurs in people over the age of 40 but is now also affecting children and adolescents to a greater extent. The older you are, the greater your risk of diabetes.

    • Obesity

    Over 80 per cent of people with type 2 diabetes are overweight. The more overweight you are, the greater your risk of diabetes.

    • A family history of diabetes

    Research has shown that people are more at risk if there is a history of diabetes in close family members. The closer the relative, the greater your risk of diabetes.

    • Physical inactivity

    Research has shown that people who do not lead an active life are more at risk of developing type 2 diabetes. The less exercise you do, the greater your chances of developing diabetes.

    • Impaired glucose tolerance (IGT)

    A healthy person’s blood sugar is usually between 70 and 110 mg/dL (milligrams of glucose in 100 millilitres of blood) or, in millimols, between 3.9 and 6.0 mmol/L. Impaired glucose tolerance is a level of blood glucose which is higher than normal, but not high enough to be in the range where doctors classify this as diabetes.

    • Race/ethnicity

    As far as we know, race and ethnicity are important in determining the possibility of a person developing diabetes. Little research, however, has been undertaken outside of the United States. Within that population, African-Americans, Hispanic Americans, Native Americans, Asian-Americans and Pacific Islanders are more likely to have diabetes.

    • Diabetes during pregnancy

    Some women develop a temporary type of diabetes called 'gestational diabetes' when they are pregnant. Gestational diabetes develops in 2-5% of all pregnancies, but usually disappears when the pregnancy is over. However, women who have had gestational diabetes or who have given birth to a large baby (4kg/2lb or greater) are at a greater risk of developing type 2 diabetes at a later stage in their lives.

    If you think that are you are at risk of developing diabetes, you should talk to a healthcare professional.

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    Klik hier om een link te hebben waarmee u dit artikel later terug kunt lezen.download

    EU Diabetes Policy Audit: following the success of the first report carried out in 2005 ('Diabetes - The Policy Puzzle: Towards Benchmarking in the EU 25'), a new edition has been published:

    IDF Europe's comment on food labelling.

    For further information on the European Region, please contact:

    Lex Herrebrugh
    Regional Manager
    IDF Europe
    Chaussée de la Hulpe 166
    B-1170 Brussels
    Belgium
    Tel: +32 2 5371889
    Fax: +32 2 5371981
    e-mail: info@idf-europe.org

    DOWNLOAD   ZIE BIJLAGE  >>>>>>>>>>>>>>

     

    Bijlagen:
    EU-diabetes-policy-audit-2008.pdf (3.2 MB)   

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    Klik hier om een link te hebben waarmee u dit artikel later terug kunt lezen.Diabetes: understanding insulin resistance

     

    When your cells become insulin resistant, they lose their sensitivity to insulin. As a result, large quantities of glucose cannot enter the cells, remaining instead, in the blood stream where it passes to the liver and is converted to fat. This process often leads to weight gain.

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    Diabetes Rap Video Clip

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    Diabetes overview

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    Klik hier om een link te hebben waarmee u dit artikel later terug kunt lezen.Diabetes partners organisaties
    Partner List
    MDHonors Club
    International Diabetes Federation Europe
    Deutsche Diabetes Stiftung
    Deutsche Diabetes Gesellschaft
    Diabetes-Kids.de
    Verband der Diabetes-Beratungs- und Schulungsberufe in Deutschland e. V.
    diabetes.de
    Diabetes Prevention Forum
    Info Diabetologie - Die Zeitschrift für interdisziplinäre Fortbildung in der Diabetologie
    MedicaMail
    EuroPharm Forum Observatory
    Polish Society of Endocrinology
    Ošetrovatelství.info - Osobní úcet
    The Finnish Diabetes Association
    Bundesverband selbstständiger Arbeitsmediziner und freiberuflicher Betriebsärzte e.V.
    National Examiners
    Associazione Nazionale Dietisti
    Diabetes Reference Group / Diabetes Education Centre
    Diabetes Cure Natural
    Pentru domeniul medical
    Development and Implementation of a European Guideline and Training Standards for Diabetes Prevention (IMAGE)
    6th World Congress on Prevention of Diabetes
    TUMAINI Institut für Präventionsmanagement GbR
    Carus Consilium Sachsen
    CrescNet - Netzwerk zur Früherkennung von Störungen der Wachstums- und Gewichtsentwicklung
    Association of Diabetes Nurse Educators of the Philippines (ADNE

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    Klik hier om een link te hebben waarmee u dit artikel later terug kunt lezen.the 6th World Congress on Prevention of Diabetes and its Complications

    Welcome

    Welcome to Germany in 2010!

    On behalf of the Local Organizing Committee it is my pleasure to invite you to participate in the 6
    th World Congress on Prevention of Diabetes and its Complications (WCPD 2010), to be held in Dresden, Germany on April 8-11, 2010.

    We know that diabetes prevention is effective but diabetes prevention presents many different faces creating unknown challenges, such as medical and psychological, but also shows political, economical, social and environmental expressions. Currently we know numerous diabetes prevention concepts which can be implemented into clinical practice in various countries worldwide, but we lack the exchange of their ideas, experiences and often problems with management.


    The 6
    th WCPD provides a great opportunity to enable a more effective communication between all people interested in diabetes prevention and its management. Here we have the opportunity to learn from the experiences of others especially discussing barriers encountered during prevention programme implementation. Our aim is to have the translation of what we have learned in Science into practical skills of prevention. We want to encourage the adoption of best practices in diabetes prevention involving a good partnership between all relevant players. Effective primary prevention is essential to reduce the epidemic of type 2 diabetes throughout the world. To achieve this, action is needed not only in the field of policy making but also in the development of targeted intervention programmes which address the needs of people with an increased risk of diabetes, clinical- and community-based healthcare professionals and the general population.
    In addition we have included other issues such as city planning aspects, funding opportunities and support for policy development because they affect the efficiency and efficacy of diabetes prevention programmes.

    We are looking forward seeing you in Dresden in 2010!

    Prof. Peter  Schwarz   Prof. Stefan  R. Bornstein
    Prof. Peter  Schwarz   Prof. Stefan  Bornstein
    Prof. Peter Schwarz
    President
        Prof. Stefan Bornstein
    Vice President
     

     Directory -  who is active in diabetesprevention

    World directory for people active in the prevention of diabetes – Register Today!

    Our aim is to bring people world wide together interested in diabetes prevention. We invite everyone who is active in the prevention of diabetes and chronic diseases - medical professionals but also lay-people, politicians, administrators, public health specialists, health care providers and many, many others - to become a partner in the network.

    We would like to establish an online world directory for “people active in diabetes prevention” to connect individuals who are interested and active in the field of prevention of diabetes mellitus.

     

    This should help to:

     

    • build up a network of people being active in the prevention of diabetes worldwide
    • exchange information and experiences leading to successful implementation of prevention programs

     

    With this network we would like to build a climate of understanding of success but also difficulties in the process of implementation.

    If you are interested please go ahead and register with your name and Email address today. Step by step we would like to extend the information based on your inputs and responses.

    Join the network "people active in diabetes prevention" and make the prevention of diabetes mellitus become reality.

    Prof. Peter Schwarz – Dresden, Germany

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    Klik hier om een link te hebben waarmee u dit artikel later terug kunt lezen.IDF Membership

    IDF Membership

    IDF membership is composed of: 

    Association membership

    IDF has three categories of association membership:

    1. Provisional members

    Between meetings of the General Council, associations may be admitted to provisional membership by the Board of Management upon the recommendation of the appropriate Regional Council.

    At the next meeting of the General Council, provisional member associations are elected to full membership (provided they have been recommended by the Board of Management).

    Provisional member associations pay an annual membership fee (equivalent to half of that which they would have to pay as a full member), for which they receive certain benefits.

    Provisional members can appoint up to two observers to the General Council.

    2. Full members

    A full member association is any national association or society that is actively concerned with diabetes or diabetes-related conditions.  An association is admitted to full membership by the General Council and pays an annual membership fee, which entitles it to special benefits.

    • Full members can appoint delegates to the General Council.
    • Full members may also nominate individuals for election to honorary membership.

    Current list of IDF full members.

    3. Associate members

    Associate member associations are national or international associations actively concerned with issues related to diabetes and related conditions and affiliated to IDF. They are admitted to membership by the Executive Board upon the recommendation of the Board of Management.

    Associate member associations pay an annual membership fee and may appoint one observer to the General Council.

    Honorary membership

    Honorary Presidents and Honorary Members are elected by the General Council from among the candidates put forward by the Special Nominating Committee. There can be a maximum of 12 Honorary Presidents.

    Honorary Presidents act as observers to the General Council.

    Further information about IDF membership can be found in the IDF Articles of Association under Part II Membership, Article 4 to 9 and Part VII, Article 31.

    If you have any additional questions regarding IDF membership please contact the IDF Executive Office.

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    Diabetes Links

    Useful links to other websites related to health

    http://www.euradia.org Alliance for European Diabetes Research

    http://www.easd.org European Association for the Studay of Diabetes

    Free Diabetes Info Downloads PDF

    http://www.pcdeurope.org Primary Diabetes Care EUROPE

    http://www.ispad.org International Society for Pediatric and Adolesent Diabetes

    http://www.ehnheart.org European Heart Network

    http://www.fend.org/ Federation of European Nurses in Diabetes

    http://www.healthfirsteurope.org Health First Europe

    http://www.epha.org/ European Public Health Alliance

    http://www.efpia.org/ European Federation of Pharmaceutical Industries and Associations

    http://www.emea.eu.int/ European Medicines Agency

    http://www.euro.who.int/ World Health Organization Regional Office for Europe

    http://www.iotf.org/ International Obesity Taskforce

    http://www.epgpatientdirect.org/page.cfm/page/348 EPG Patient Direct

    http://www.cardiometabolic-risk.org/home/index.html International Chair on Cardiometabolic Risk

    http://www.diabetes.co.uk Diabetes.co.uk, the global diabetes community

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    Klik hier om een link te hebben waarmee u dit artikel later terug kunt lezen.What is Diabetes

    WHAT IS DIABETES?

    Diabetes is recognized as a group of heterogeneous disorders with the common elements of hyperglycaemia and glucoseinsulin deficiency, impaired effectiveness of insulin action, or both intolerance, due to  1 . Diabetes mellitus is classified on the basis of aetiology and clinical presentation of the disorder into four types.

    • type 1 diabetes,
    • type 2 diabetes,
    • gestational diabetes mellitus (GDM), and
    • other specific types.


    Type 1 diabetes

    Type 1 diabetes is sometimes called insulin-dependent, immune-mediated or juvenile-onset diabetes. It is caused by destruction of the insulin-producing cells of the pancreas, typically due to an auto-immune reaction, where they are attacked by the body's defense system. The beta cells of the pancreas therefore produce little or no insulin, the hormone that allows glucose to enter body cells. The reason why this occurs is not fully understood.

    The disease can affect people of any age, but usually occurs in children or young adults. Type 1 diabetes is one of the most common endocrine and metabolic conditions in childhood. People with type 1 diabetes need injections of insulin every day in order to control the levels of glucose in their blood. Without insulin, people with type 1 diabetes will die.

    The onset of type 1 diabetes is often sudden and dramatic and can include symptoms such as:

    • abnormal thirst and a dry mouth
    • frequent urination
    • extreme tiredness/lack of energy
    • constant hunger
    • sudden weight loss
    • slow-healing wounds
    • recurrent infections
    • blurred vision

    The incidence of type 1 diabetes is increasing, the reasons for which are unclear but are likely to be mainly due to changes in environmental risk factors. Environmental risk factors, increased height and weight development, increased maternal age at delivery, and possibly some aspects of diet and exposure to some viral infections may initiate autoimmunity or accelerate an already ongoing beta cell destruction.

    Type 2 diabetes

    Type 2 diabetes is characterized by insulin resistance and relative insulin deficiency, either of which may be present at the time that diabetes becomes clinically manifest. The diagnosis of type 2 diabetes usually occurs after the age of 40 years but could occur earlier, especially in populations with high diabetes prevalence. There are increasing reports of children developing type 2 diabetes. Type 2 diabetes can remain undetected, i.e. asymptomatic, for many years and the diagnosis is often made from associated complications or incidentally through an abnormal blood or urine glucose test.

    Type 2 diabetes is often, but not always, associated with obesity, which itself can cause insulin resistance and lead to elevated blood glucose levels. It is strongly familial, but major susceptibility genes have not yet been identified. There are several possible factors in the development of type 2 diabetes. These include:

    • Obesity, diet and physical inactivity
    • Increasing age
    • Insulin resistance
    • Family history of diabetes
    • Less than optimum intrauterine environment
    • Ethnicity

    In contrast to type 1 diabetes, people with type 2 diabetes are not dependent on exogenous insulin and are not ketosis-prone, but may require insulin for control of hyperglycaemia if this is not achieved with diet alone or with oral hypoglycaemic agents.

    The rising prevalence of type 2 diabetes is associated with rapid cultural and social changes, ageing populations, increasing urbanization, dietary changes, reduced physical activity and other unhealthy lifestyle and behavioural patterns 2 .

    Gestational diabetes

    Gestational diabetes mellitus (GDM) is a glucose intolerance of varying degrees of severity which starts or is first recognized during pregnancy. The definition applies regardless of whether insulin is used for treatment or if the condition persists after pregnancy.

    Maintaining control of blood glucose levels significantly reduces the risk to the baby as an increased maternal glucose level could result in complications in the baby including large size at birth, birth trauma, hypoglycaemia and jaundice. Women who have had GDM have an increased risk of developing type 2 diabetes in later years. GDM is also associated with increased risk of obesity and abnormal glucose metabolism during childhood and adult life in the offspring.

    Diabetes complications

    In virtually every high-income country, diabetes is ranked among the leading causes of blindness, renal failure and lower limb amputation. Diabetes is also now one of the leading causes of death, largely because of a markedly increased risk of coronary heart disease and stroke (cardiovascular disease). In addition to the human suffering that diabetes-related complications cause, to those with diabetes but also to their carers, their economic costs are huge. Costs include those for healthcare, loss of earnings, and economic costs to the wider society in loss of productivity and associated lost opportunities for economic development. 

    Chronic elevation of blood glucose, even when no symptoms are present to alert the individual to the presence of diabetes, will eventually lead to tissue damage, with consequent, and often serious, disease. Whilst evidence of tissue damage can be found in many organ systems, it is the kidneys, eyes, peripheral nerves and vascular tree, which manifest the most significant, and sometimes fatal, diabetes complications (see Figure 1.1).

    Unsatisfactory metabolic control in children can result in stunted growth, and exposure to both severe hypoglycaemia and chronic hyperglycaemia can adversely affect neurological development. Children are more sensitive to a lack of insulin than adults and are at a higher risk of a rapid and dramatic development of diabetic ketoacidosis (diabetic coma).

    The mechanism by which diabetes leads to these complications is complex, and not yet fully understood, but involves the direct toxic effects of high glucose levels, along with the impact of elevated blood pressure, abnormal lipid levels and both functional and structural abnormalities of small blood vessels.

    The major chronic complications of diabetes are:

    • cardiovascular disease (CVD);
    • nephropathy;
    • neuropathy;
    • amputation; and
    • retinopathy.

    Cardiovascular disease


    Cardiovascular disease is the major cause of death in diabetes, accounting in most populations for 50% or more of all diabetes fatalities, and much disability. The kinds of CVD that accompany diabetes include angina, myocardial infarction (heart attack), stroke, peripheral artery disease, and congestive heart failure (CHF).

    Nephropathy


    Diabetes is an increasingly important cause of renal failure, and indeed has now become the single most common cause of end stage renal disease, i.e. that which requires either dialysis or kidney transplantation, in the USA
    http://www.usrds.org/adr.htm] fade=[on] fadespeed=[0.05]"> 3 , and in other countries.

    Neuropathy


    When blood glucose and blood pressure are not controlled, diabetes can harm the nerves. Problems with digestion and urination, impotence, and many other functions can result, but the most commonly affected area is the feet and legs. Nerve damage in these areas is called peripheral neuropathy and could manifest in many ways including loss of feeling in the feet and toes. Loss of feeling is a particular risk because it can allow foot injuries to escape notice and treatment, leading to major infections and amputation.

    Amputation
    Through effects on peripheral nerves and arteries, diabetes can lead to foot ulceration, infection and the need for amputation. People with diabetes carry a risk of amputation that may be more than 25 times greater than that seen in those without diabetes
     4 .

    Retinopathy
    Diabetes can harm sight and cause blindness in several ways. The most common cause of blindness in diabetes is macular oedema, caused by fluid build-up behind the retina of the eye. A more common complication is background and proliferative retinopathy, which can cause blindness as a result of repeated haemorrhages at the back of the eye. Diabetes also increases the risk of cataracts and glaucoma.

    The major diabetes complications

    Impaired glucose tolerance

    Impaired glucose tolerance (IGT) is an asymptomatic condition defined by elevated (though not diabetic) levels of blood glucose two hours after a 75g oral glucose challenge. Along with impaired fasting glucose (IFG), it is now recognized as being a stage in the transition from normality to diabetes. Not surprisingly, IGT shares many characteristics with type 2 diabetes, being associated with obesity, advancing age, insulin resistance and an insulin secretory defect.

    Insulin

    Insulin is the internal secretion of the pancreas formed by groups of cells called the islets of Langerhans. It is the hormone needed to enable glucose to enter the cells and provide energy. Insulin is also important in keeping blood glucose levels within acceptable limits.

    Insulin is injected into the body by people with type 1 diabetes in whom the cells that produce insulin have been destroyed. This is the most common form of diabetes in children and young adults, and they depend on insulin for survival. Insulin may also be used by people with type 2 diabetes. In type 2 diabetes, the body needs more insulin than it can produce.

    Since the landmark discovery of insulin by Frederick Banting and Charles Best in 1921, huge steps forward have been made in research and development in creating genetically engineered human insulin. Until relatively recently insulin was derived from a limited resource of the pancreas of cattle and pigs.

     

    Insulin production and action


    1: Harris M, Zimmet P. Classification of diabetes mellitus and other categories of glucose intolerance. In Alberti K, Zimmet P, Defronzo R, editors. International Textbook of Diabetes Mellitus. Second Edition. Chichester: John Wiley and Sons Ltd; 1997. p9-23.
    2: World Health Organization. Prevention of diabetes mellitus. Report of a WHO Study Group. Geneva: World Health Organization; 1994. No. 844.
    3: United States Renal Data System. Annual Data Report. 2002. http://www.usrds.org/adr.htm
    4: Davis TM, Stratton IM, Fox CJ, et al. U.K. Prospective Diabetes Study 22. Effect of age at diagnosis on diabetic tissue damage during the first 6 years of NIDDM. Diabetes Care 1997; 20 (9): 1435-1441.


    SHORTFACTS

    What is diabetes?

    Diabetes is an illness which occurs as a result of problems with the production and supply of insulin in the body.

    Most of the food we eat is turned into glucose, a form of sugar. We use glucose as a source of energy to provide power for our muscles and other tissues. Our bodies transport glucose in our blood. In order for our muscles and other tissues to absorb glucose from our blood, we need a hormone called insulin. Without insulin, our bodies cannot obtain the necessary energy from our food.

    Insulin is made in a large gland behind the stomach called the pancreas. It is released by cells called beta cells. When a person has diabetes, either their pancreas does not produce the insulin they need, or their body cannot use its own insulin effectively.

    As a result, people with diabetes cannot use enough of the glucose in the food they eat. This leads to the amount of glucose in the blood increasing. This high level of glucose or "high blood sugar" is called hyperglycaemia. High levels of glucose in the blood can lead to serious complications.

    At present there is no cure for diabetes.

    The International Diabetes Federation estimates that more than 245 million people around the world have diabetes. This total is expected to rise to 380 million within 20 years. Each year a further 7 million people develop diabetes.

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    NIck Jonas Discusses his Diabetes & Surprises a fan!

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    19-03-2010
    Klik hier om een link te hebben waarmee u dit artikel later terug kunt lezen.Vraag en antwoord

    Veelgestelde vragen met antwoorden over diabetes.

    • Is diabetes hetzelfde als suikerziekte?
    • Als je veel afvalt, hoef je dan geen insuline meer te spuiten?
    • Is diabetes te genezen?
    • Wat mag iemand met diabetes eten?
    • Mag je met diabetes sporten?
    • Mag je zwanger worden als je diabetes hebt?
    • Hoeveel suiker (glucose) mag er in je bloed zitten?
    • Kun je donor worden als je diabetes hebt?
    • Wat is HbA1c?
    • Verlaagt kaneel de bloedsuiker?
    • Wat is de invloed van stress op diabetes?
    • Ik ben vaak misselijk, komt dat door mijn medicijnen?
    • Waarom wordt roken extra afgeraden bij diabetes?
    • Als je geen medicijnen meer nodig hebt, ben je dan van diabetes af?
    • Waarom moet ik méér insuline spuiten als ik ziek ben?
    • Waarom is afvallen goed als je diabetes hebt?
    • Waarom ruiken mensen met diabetes soms naar aceton?
    • Kunnen huisdieren diabetes krijgen?
    • Zijn er hulphonden voor diabetes?
    • Zijn voedingsmiddelen gezoet met fructose beter?
    • Is er geen betere naam dan ‘diabetes type 1 of type 2'?

    Staat uw vraag er niet bij? Stel uw vraag met het contactformulier.

    Meedoen met onderzoek

    Veelgestelde vragen met antwoorden over als proefpersoon deelnemen aan onderzoek.

    • Heb ik zelf wat aan deelname als proefpersoon?
    • Kan ik me opgeven om mee te doen met een onderzoek?
    • Wat moet ik doen voor een onderzoek?
    • Kan ik stoppen als het tegenvalt?
    • Waar wordt onderzoek gedaan?
    • Krijg ik een vergoeding voor het meedoen?
    • Kan mijn kind meedoen met onderzoek?
    • Moet ik het vertellen aan mijn huisarts?
    • Kan er wat misgaan?
    • Wat gebeurt er na het onderzoek?

    Staat uw vraag er niet bij? Stel uw vraag met het contactformulier.

    Diabetes voorkomen

    Veelgestelde vragen met antwoorden over diabetes voorkomen.

    • Ik snoep nooit, kan ik dan toch diabetes krijgen?
    • Is diabetes erfelijk?
    • Waar kan ik mij laten testen op diabetes?
    • Kun je van prednison diabetes krijgen?

    Staat uw vraag er niet bij? Stel uw vraag met het contactformulier.

    Onderzoek

    Veelgestelde vragen met antwoorden over onderzoek naar diabetes.

    • Wat is medisch onderzoek?
    • Waarom wordt medisch onderzoek gedaan?
    • Wie doen onderzoek?
    • Waar komt het geld voor onderzoek vandaan?
    • Aan welk soort onderzoek geeft het Diabetes Fonds geld uit?
    • Betaalt het Diabetes Fonds mee aan medicijnen, dus de farmaceutische industrie?
    • Waarom kost wetenschappelijk onderzoek zoveel geld?
    • Wie bepaalt welk onderzoek gebeurt?
    • Betaalt de overheid mee aan onderzoek naar diabetes?

    Staat uw vraag er niet bij? Stel uw vraag met het contactformulier.

    Steunen

    Veelgestelde vragen met antwoorden over steun aan het Diabetes Fonds.

    • Waarom zou ik het Diabetes Fonds steunen?
    • Waarom zou ik het Diabetes Fonds steunen, als ik zelf geen diabetes heb?
    • Er is iemand bij mij aan de deur geweest met de vraag of ik donateur wil worden. Is dat wel iemand van het Diabetes Fonds?
    • Klopt het dat mijn geld deels besteed wordt aan de kosten die externe wervingsorganisaties maken?
    • Waarom vraagt u voor een download van een brochure mijn adresgegevens?
    • Ik ben laatst gebeld namens het Diabetes Fonds met het verzoek of ik donateur wil worden. Hoe zit dit precies?
    • Donateur worden via SMS. Hoe zit dit precies?
    • Ik ben laatst gebeld om mee te spelen aan de Sponsor Bingo Loterij. Wat heeft dit met uw stichting te maken?

    Staat uw vraag er niet bij? Stel uw vraag met het contactformulier.

    Notarieel schenken

    Veelgestelde vragen met antwoorden over notarieel schenken.

    • Wat is dat, periodiek schenken via een notariële akte?
    • Hoe werkt het in het kort?
    • Wat is het grote voordeel van periodiek schenken via een notariële akte?
    • Hoe betaal ik aan het Diabetes Fonds?
    • Waarom zou ik schenken via een notariële akte?
    • Wat is mijn fiscaal voordeel?
    • Hoe geef ik mijn schenking via notariële akte aan op het belastingformulier?
    • Hoe krijg ik het bedrag uitbetaald van de fiscus?
    • Kan ik het bedrag van de fiscus ook via een ‘Beschikking loonbelasting' uitgekeerd krijgen?
    • Wie bepaalt de hoogte van het bedrag?
    • Voor hoelang kan ik op deze wijze schenken?
    • Kan ik zelf bepalen wanneer ik begin met de periodieke schenking?
    • Moet ik voor het afsluiten naar de notaris?
    • Kan ik tussentijds stoppen met de notariële akte?
    • Als ik kom te overlijden, moeten mijn erfgenamen dan mijn verplichting overnemen?

    Staat uw vraag er niet bij? Stel uw vraag met het contactformulier.

    Collecte

    Veelgestelde vragen met antwoorden over de collecte van het Diabetes Fonds.

    • Wat gebeurt er met het geld dat ik ophaal met de collecte?
    • Waarom een collecte?
    • Waarom is de collecte altijd in de herfst?
    • Staat uw vraag er niet bij?

    Bookmark and Share

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    17-03-2010
    Klik hier om een link te hebben waarmee u dit artikel later terug kunt lezen.on line resources

    Online Insulin and Diabetes Resources

    Places to go for additional information about insulin and diabetes:

    American Diabetes Association

    Founded in 1940, the American Diabetes Association was formed to help support patients with diabetes.
    Phone (Toll-free):
    1-800-DIABETES
    Web:
    www.diabetes.org

    American Association of Diabetes Educators

    An association of healthcare professionals dedicated to integrating successful self-management as a key outcome in the care of people with diabetes and related conditions.
    Web:
    www.diabeteseducator.org

    American Dietetic Association

    The world's largest organization of food and nutrition professionals. ADA is committed to improving the nation's health and advancing the profession of dietetics through research, education and advocacy.
    Web:
    www.eatright.org/

    American Association of Clinical Endocrinologists

    The American Association of Clinical Endocrinologists (AAC) is a medical professional community of clinical endocrinologists committed to enhancing its members' ability to provide the highest quality of care. Public resources on their website include Find an Endocrinologist (a physician locator) and My Endocrine Disorder (a list of online resources sorted by condition).
    Phone:
    1-904-353-7878
    Web:
    www.aace.com

    dLife. For Your Diabetes Life

    A leading online diabetes resource, dLife offers information and community support for type 1 diabetes, type 2 diabetes, and caregivers – from questions about blood sugar to delicious diabetic recipes.
    Web:
    www.dlife.com

    Institute for Diabetes, Obesity and Metabolism

    The IDOM was established in 2005, at a time of ever increasing prevalence of diabetes and obesity. IDOM was formed to support and develop successful approaches for the treatment of diabetes mellitus and obesity.
    Web:
    www.med.upenn.edu/idom/

    International Diabetes Center

    International Diabetes Center at Park Nicollet has provided world-class diabetes care, education, and research that meet the needs of people with diabetes and their families since 1967.
    Web:
    www.parknicollet.com/diabetes/

    Joslin Diabetes Center

    Joslin Diabetes Center is the only diabetes institution in the world that goes beyond a single focus: research, care and education. This one-of-a-kind framework has an impact on people with diabetes locally, nationally and across the globe.
    Phone:
    1-617-732-2400
    Web:
    www.joslin.org

    17-03-2010, 12:46 Geschreven door diabetesinsiders  

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