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1: 10: 10 / Erlangen - Erlangen researchers have found a new approach for therapy and prevention of breast cancer.
The international team showed how some hormones promote the growth of breast cancer, said the University of Erlangen- Nuremberg on Friday.
The results are in the journal " Nature" published. The relationship between the administration of certain hormone preparations and breast cancer has long been known. The exact mechanism, however, recipient of the hormones, the uncontrolled cell proliferation, had been unclear, " added the university. Cells of the mammary gland have receiver molecules ( receptors) for estrogen and progesterone. Especially medroxyprogesterone, which is used in the three- month injection for the prevention, and other synthetic progestogens increase the risk of breast cancer.
Scientists have now discovered that a signaling protein called progesterone affect RANKL.
This is for the construction and removal of bone is important. Under the influence of progesterone RANKL is also produced in the female breast. It then promotes cell growth in the mammary gland and also increased the stem cells that are responsible for the development of breast cancer.
This helps the development of malignant tumors. Already, the protein can inhibit RANKL. " The findings of the relationships between progesterone and RANKL arise in the future better facilities for the treatment of patients with breast cancer but also for the prevention of tumor development, since changes of RANKL precede the clinical manifestation of the disease, " continues the researcher. Breast cancer in Western industrialized nations, the most common cancer in women - one in ten suffer throughout their lives to it.
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