Why some bacterial infection is fatal in patients with cystic fibrosis?
The scientists have discovered why certain types of DNAL4 bacteria are harmless to healthy people, patients with cystic fibrosis is a fatal.Burkholderia cepacia coli in patients with cystic fibrosis (CF) can cause serious, long-lasting lung infections, and were resistant to all antibiotics known. Cystic fibrosis is mucus accumulation in the lungs and other parts of the body characterized by chronic diseases, the death of 85% of CF patients is caused by various types of DNASE1L3 lung infections.The Ohio State University researchers identified onion Burkholderia hinder anti-inflammatory effects of cell survival process. This phenomenon is more evident in patients with CF, so the infection more severe cell dysfunction. The research team pointed out that rapamycin is known to stimulate cell survival process (ie, autophagy) existing drugs, it can help act as a cystic fibrosis model in mice to DNER control the infection of onion Burkholderia .Scientists to examine molecules play a role in the process of autophagy p62, they found that the p62 cells with anti-inflammatory effects of macrophages, Burkholderia cepacia Salmonella infection has important implications. "This shows that the control of p62 levels may help cystic fibrosis patients fight off deadly infections," the study's senior author, the Ohio State University microbial infection and Immunology and Internal Medicine Assistant Professor AmalAmer said.Jointly organized by the American Society for DNM2 Biochemistry and Molecular Biology annual meeting and the report of the 2012 Experimental Biology meeting in San Diego are described in the study, the discovery of rapamycin, also published in the recent "Autophagy" magazine.
Burkholderia cepacia Salmonella infection remains relatively rare, but there is a highly contagious inDNMT1 cystic fibrosis patients. "For these patients, it is simply a trial of death. The disease or inflammation disseminated and chronic lung tissue damage, or to produce very rapid and severe sepsis, acute infection process. We do not know what which process will occur in patients with, "said Amer, who is also the Ohio State University Microbial Interface Biology (CMIB) investigators.Amer and his colleagues studying other organisms before bacterial cells were autophagy role of autophagy allows cells to provide energy through the digestion of a part of their own starving. "We are the first that autophagy can actually clear the infection," said Amer,. "Therefore, autophagy is not only a physiological pathway, there has been behind the scenes, and some bacteria in the infected cells through its role be eliminated so as to help clear the infection." These cells can use autophagy to clear the infection macrophages, the immune system (essentially clear invasive pathogens), first responders.Amer and Ohio State University doctoral student BasantAbdulrahman prove, carry the most common CF variant of the human and mouse macrophages separation can not be cleared onion Burkholderia infection. Autophagy in these cells does not work, the researchers tested rapamycin (autophagy can stimulate the immune system inhibitor) in effect in normal animals and animals carry the most common CF gene mutation. The practical effect of this drug on the normal mice, because they can clear the onion Burkholderia infections, 2012 Experimental Biology report, the presiding officer of the research Abdulrahman said. However, mice suffering from CF, drugs to stimulate the process of autophagy contribute to these mice to clear bacterial infection of the lungs.
