Lee Grant produced a wonder-save to help Sheffield Wednesday hold out for a goalless draw at Southampton.
Grant frustrated the hosts when he somehow tipped Bradley Wright-Phillips' goalbound effort around the post.
The Owls also threatened, with Burton O'Brien testing Saints keeper Kelvin Davis and Richard Hinds heading over from the resulting corner.
Adam Hammill shot wide when well placed for Southampton and he was denied again by Grant from 18 yards before the end.
Southampton boss George Burley: "It's disappointing to create so many chances and I felt we deserved to get the three points.
"Stern John has been magnificent for us recently and has scored some very good goals, but it wasn't his day.
"Bradley Wright-Phillips had some great chances to score as did others in the team, but unfortunately we couldn't take them."
Sheffield Wednesday boss Brian Laws on Saints looking for revenge after the Owls' 5-0 win last month: "They are still smarting and I knew they would really come at us.
"I felt we dealt with that really well and got the ball down and played some nice football at times.
"We would always take a point from a difficult away trip when you have come so far on a Tuesday night."
Ipswich made it 12 home wins on the spin and moved up to fourth by brushing aside Southampton with Jon Walters and Pablo Counago netting in either half.
Walters opened the scoring 11 minutes before half-time when he deflected a shot past Saints keeper Kelvin Davis.
Southampton did put pressure on with Ipswich keeper Neil Alexander saving from Bradley Wright-Phillips and Stevie Hammell hitting the post from 20 yards.
But Counago made the points safe with a thumping header in the 69th minute.
Ipswich manager Jim Magilton: "We were lucky with the first goal and were a little bit nervy. It was a scrappy win but I am delighted with a clean sheet and three points.
"We had to dig in and we did. In the end we showed that little bit more quality which made the difference.
"There were times when we were a little bit low but the crowd lifted us and the players appreciated it."
Ipswich: Alexander, Wright, Bruce, De Vos, Harding, Walters, Miller (Legwinski 90), Garvan (Williams 67), Clarke (Haynes 85), Counago, Lee. Subs Not Used: Supple, Wilnis.
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